This session will describe the advances and utility of neuroimaging for pain. Specifically, it will provide a contemporary overview of neuroimaging of the brain, brainstem and spinal cord. It will outline how neuroimaging has advanced the understanding of acute and chronic pain, as well as how cognitive and emotional factors contribute to the magnification and persistence of pain. The neuroscience of placebo and expectations and how this knowledge can translate into better understanding of our patient’s response to treatment will also be discussed. Finally, current efforts and results in development of objective brain/spinal cord biomarkers to (1) predict treatment responses; (2) prognose course of pain; (3) identify those susceptible to the development of chronic pain after injury will be discussed. The session will conclude with an interactive Q&A session to address the current and future uses of neuroimaging in pain.
Neuroimaging of Pain: Overview and Impressions
Katherine Martucci, PhD
Placebos and Painkillers: Is Mind as Real as Matter
Luana Collaca, PhD
Brain-Based Biomarkers of Pain: Advancing the Goal of Precision Pain Medicine
Sean Mackey, MD PhD
- Discuss the role of neuroimaging in elucidating the central mechanisms involved in pain processing, perception and plasticity.
- Recognize the cognitive and emotional factors that modulate our experience of pain, our individual differences in pain perception and analgesia, and the central neural correlates of these phenomena.
- Discuss the neuroimaging results that have advanced our understanding of placebo and nocebo in the experience and treatment of pain.
- Describe the role of brain neuroimaging in the detection and classification of acute and chronic pain
- Review the validity requirements for a neuroimaging based measurement of pain to be clinically useful as a tool for precision pain medicine.
- Review the ethical, privacy, and legal implications of a brain imaging-based objective measure of pain.